There is a remarkable increase in male estrogen levels
that occur with aging. High estrogen levels in both
men and women usually lead to cancer or other
illnesses often associated with aging, including
prostate disease, breast and uterine cancers, and
weight gain.
Supplementing the diet with DIM and eating
cruciferous vegetables increases the specific aerobic
metabolism for estrogen, multiplying the chance for
estrogen to be broken down into its beneficial, or
"good" estrogen metabolites. These
"good" estrogen metabolites are known as the
2-hydroxy estrogens. Many of the benefits that are
attributed to estrogen, which include its ability to
protect the heart and brain with its antioxidant
activity, are now known to come from these
"good" metabolites.
When DIM increases the "good" estrogen
metabolites, there is a simultaneous reduction in the
levels of undesirable or "bad" estrogen
metabolites. These include the 16-hydroxy estrogens,
which are not antioxidants and can actually cause
cancer.
Greater production of these "bad"
estrogen metabolites is promoted by obesity and
exposure to a number of manmade environmental
chemicals. These "bad" estrogen metabolites
are responsible for many of estrogen's undesirable
actions in women and men, including further unwanted
weight gain, breast cancer, uterine cancer, and
prostate cancer.
DIM is highly recommended for women on HRT or at
risk for breast cancer as it will reduce the toxic
effects to estrogen dominance. "Regarding the
ratio of 2-OH-estrone to 16-alpha-estrone, which is
newer to me, I can inform you that a poor 2/16 ratio
(lower 2OH : higher 16-alpha) has been shown to be
carcinogenic. Extracts of cruciferous vegetables such
as I3C (indole-3-carbinole) and its more absorbable
metabolite DIM (di-indolyl-methane) apparently improve
this ratio thru up-regulation of the CYP1A2 liver
enzymes involved in the metabolism of estrogens
(Cancer Lett 1997;114(1-2):169-170).
In fact, DIM has been shown to induce a favorable
2/16 ratio and induce apoptosis in breast cancer cells
(Biochem Pharmacol 1999; 58(5):825-34, Carcinogenesis
1998; 19(9):1631-9). In addition, I3C also improved
2/16 ratios and induced a complete regression in 50%
of patients with cervical dysplasia of CIN II-III (Gynecol
Oncol 2000;78(2):123-9).
DIM may Prevent Cervical Cancers and genital warts
says Yale Researcher NIH funds human trials at Yale
Medical Center.
Price Comparison: Do not pay too much for
DIM. LEF and its affiliate Enzymatic Therapy charge
$47.95 for 60 capsules, 120 mg. We manufacture
the DIM ourselves and pass the savings on to you.
Remember, this is a supplement you take for a
lifetime, so you need a good price.
Published clinical studies show adults need 200 mg
of regular DIM a day to be effective. No
"absorption system" of any kind is needed
nor used in the scientific literature. Companies who
sell useless 75 mg doses with patented
"absorption systems" are just selling you an
inferior product at an inflated price.
PRODUCT
DESCRIPTION
BioResponse-DIM™
(patented, enhanced bioavailability complex containing
25% diindolylmethane, 
