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Alpha Lipoic Acid

PRODUCT DESCRIPTION
Alpha lipoic acid neutralizes both water-soluble and fat-soluble free radicals, and it helps recycle other antioxidants like vitamins C and E.
     
     
  INGREDIENTS  
   
     
  MORE INFORMATION  
 
AcidAlpha-Lipoic Acid is a powerful antioxidant that is soluble in both fat and water. It directly recycles vitamin C and indirectly recycles vitamin E, providing additional antioxidant protection. It is also an important component in the energy production process in the cells. Alpha-lipoic acid is a coenzyme that assists in the conversion of pyruvate to acetyl-coA. Acetyl-coA is the beginning point for the Krebs cycle, one of the body's main energy production cycles, which produces the high-energy molecule ATP. Alpha-lipoic acid supports the immune system and also supports healthy liver function.

General Description
Alpha lipoic acid, or ALA (also known as thioctic acid) is an antioxidant fatty acid produced naturally in the body and found in foods such as red meat, liver, brewer's yeast and green plants. ALA supplements use the synthetic form dl-alpha lipoic acid.

Health applications

  • Antioxidant protection
  • Cardiovascular health
  • Liver health
  • Diabetes
  • Immune system support
Primary functions
The body requires ALA for production of ATP (adenosine triphosphate), the main source of cellular energy. ALA also acts as an antioxidant, effective against both water-soluble and fat-soluble free radicals.1 Research shows that ALA also helps regenerate other antioxidants inlcuding vitamin C, vitamin E,1,2 and glutathione.3-5 The antioxidant capabilities of ALA make it especially beneficial for the immune system, the liver, and the cardiovascular system.

Cardiovascular health
The benefits ALA provides for the cardiovascular system stem from its role as an antioxidant. Research shows that ALA inhibits the oxidation of LDL (the "bad cholesterol").6 Oxidized LDL is a major contributor to atherosclerosis. In vitro research indicates ALA may inhibit atherosclerosis progression at its earliest stages.7 ALA also works synergistically with vitamin C to recycle vitamin E, a vitamin known to be essential for cardiovascular health.

Diabetes
The most promising research on the health benefits of ALA supplementation involves its potential in the treatment of type II  (non-insulin-dependent diabetes mellitus, or NIDDM). Research indicates that ALA can enhance insulin sensitivity,8 improve glucose effectiveness,9 and enhance glucose disposal10 in patients with NIDDM. Numerous other studies show that ALA can improve symptoms of NIDDM-related nervous system disturbances11-15 and cardiovascular problems.14-16 Because ALA supplementation may alter blood sugar and insulin levels, people with diabetes should only take ALA under a physician's supervision.

Immune system support
As an antioxidant, ALA may provide specific benefits for immune system function. By increasing plasma and intracellular levels of glutathione, ALA should, theoretically, improve the body's resistance to a variety of illnesses. Many researchers believe ALA may one day play an important role in treatment of human immuno-deficiency virus (HIV). Although studies have shown that ALA can inhibit replication of HIV in vitro,17-20 its effectiveness in human subjects has not been established.

Dosage/toxicity
Although ALA is not considered to be essential in the diet because it can be manufactured in the body, some scientists recommend supplementing 20 to 50 mg per day to boost antioxidant levels.21 ALA has an excellent safety record, with no serious side-effects reported in over 30 years of clinical research. Although studies on diabetic patients have used as much as 1,800 mg of ALA per day, there is little evidence of additional benefit in doses greater than 600 mg per day.8,14

 

More Information:

Alpha Lipoic Acid (thioctic acid) is a powerful antioxidant that supports healthy glucose metabolism, healthy energy levels and healthy immune function. Alpha Lipoic Acid is also known to maintain healthy liver function

ALPHA LIPOIC is a powerful antioxidant that works with other nutrients such as vitamins C & E and gluththione to defend against excessive free radicals. It is called an universal antioxidant because it is soluble in both water and lipid based tissue.

ALPHA LIPOIC is used by the body to metabolize food and for energy production.

Alpha-lipoic acid is an antioxidant that may prevent free-radical damage.

Although there have been hundreds of studies over the last 40 years revealing how lipoic acid energizes metabolism, the new excitement about this vitamin-like substance can be seen in the countless recent studies focusing on how it improves the physique, combats free radicals, protects our genetic material, slows aging, and helps protect against heart disease, cancer and many other diseases.

Richard A. Passwater, Ph.D., in Lipoic Acid: The Metabolic Antioxidant states, "Both insulin-dependent and non-insulin-dependent diabetics will be excited to learn that lipoic acid has been used for nearly 30 years in Europe to treat diabetic neuropathy, help regulate blood sugar and prevent diabetic retinopathy and cardiopathy." He continues, "Lipoic acid not only protects the nervous system, but also may be involved in regenerating nerves. It is also being studied in the treatment of Parkinson's disease and Alzheimer's disease."

Although we make some lipoic acid in our bodies, it is usually not enough, so we rely on food - potatoes, red meat, etc. - to supply what we need for optimal health. Alpha-lipoic acid supplements are now available in health food stores to ensure that we get a sufficient intake of the nutrient.

Passwater adds that lipoic acid's antioxidant function is of major importance, since antioxidant nutrients help protect the body against the damage that can cause heart disease, cancer, aging and about 80 other diseases. This damage is a result of the presence of free radicals, or undesirable byproducts of metabolism.

Interaction with vitamins C & E

As mentioned above, another function of the lipoic acid is that it both interacts with its antioxidant partners vitamin E and vitamin C and also helps to conserve them. When the body is deficient in lipoic acid, the other antioxidants do not properly network together.

"Lipoic acid has also been used for decades to protect the liver and to detoxify the body of heavy metal pollutants, such as excessive iron and copper and toxic metals such as cadmium, lead and mercury," Passwater continues. One of the most exciting recent developments is that lipoic acid appears to help slow down the progression of HIV-infection to clinical AIDS.

It appears that alpha-lipoic acid, alone or together with vitamin E or C, is an effective treatment for radiation exposure, lessening indices of oxidative damage and normalizing organ function, according to Lester Packer, Ph.D., et al. in Free Radical Biology and Medicine 1995. This therapy has been effective in treating children living in areas affected by the Chernobyl tragedy in the former Soviet Unlon.

Neither animal nor human studies, so far, have shown serious side effects with the use of alpha-lipoic acid, Packer says. However, it is not recommended for pregnant women without proper supervision since it may interfere with vitamin B-1 utilization. A thiamine supplement may be warranted if lipoic acid is given to thiamine-deficient individuals, such as alcoholics.

Protection from cataract formation

Writing in a previous issue of Free Radical Biology and Medicine, I. Maitra, et al., reported that, when lab animals were treated with buthionine sulfoximine (BSO), they all developed cataracts. However, supplementation with lipoic acid protected 60 per cent of the BSO-treated animals from cataract formation.

Maitra and colleagues added that concentrations of glutathione, vitamin C and vitamin E, which decrease after BSO administration, were restored to levels similar to the controls. Lipoic acid also restored the protein complexes glutathione peroxidase and catalase, as well as ascorbate free radical reductase activities in the lens of the animals.

Hans-J. Tritschler, Ph.D., a well-known researcher of lipoic acid, says that the substance is a very important co-factor for glucose metabolism. And, since it is both fat- and water-soluble, it is the missing link between the metabolism of vitamin E and C.

"Since there isn't an overwhelming amount of alpha-lipoic acid in our bodies, an expert panel has recommended 50 mg/day as a preventive measure against diseases caused by free-radical attacks," Tritschler says.

Bogus Claims Warning

Our Alpha Lipoic Acid combines both R and S isomers which is exactly what is used in all of the published studies. Promoters that claim only one isomer is valid are completely unscientific; if you look up their supposed "reference" you will see that the quoted studies are grossly misrepresented. Do not pay more to promoters who want to charge you outrageous prices for an inferior product.
 
 
     
**For your information: The products and the claims made about specific products on or through this site have not been evaluated by the United States Food and Drug Administration and are not intended to diagnose, treat, cure or prevent disease. The information provided on this site is for informational purposes only and is not intended as a substitute for advice from your physician or other health care professional or any information contained on or in any product label or packaging. You should not use the information on this site for diagnosis or treatment of any health problem or for prescription of any medication or other treatment. You should consult with a healthcare professional before starting any diet, exercise or supplementation program, before taking any medication, or if you have or suspect you might have a health problem.*


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* RDA means the Recommended Daily Allowance established by the U.S. Food and Drug Administration. This is the minimum daily amounts of specific essential nutrients necessary for healthy adults 18 year of age. Requirements increase with age and the RDA may be insufficient for older adults or those with poor health.*

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