Rye Pollen Flower provides relief for many prostate-related issues that are experienced by the majority of men over 40-years of age. The main ingredient is rye pollen. All possible allergens and impurities are removed by a very sophisticated and complex process. GramminexT can yield prostate health benefits within weeks, rather than the months which are typical of other nutritional supplements for prostate health.

>Rye Pollen Flower has been shown to provide the following benefits:

• Reduction in prostate congestion
• Decrease number of nighttime bathroom trips (urinary frequency) urinary urgency and hesitancy
• Improved ability to fully empty the bladder (via relaxation of urethral smooth muscles); also helps women with bladder control issues
• Inhibition of the binding of 5-alpha-dihydrotestosterone (DHT) to prostate cells
• Rye Pollen Flower can yield prostate health benefits within weeks, rather than the months which are typical of other nutritional supplements for prostate health.
• Rye Pollen Flower has a calming effect upon spasms of the musculature of the smooth muscles of the urethra and bladder neck. It improves contractibility of the bladder and reduces inflammation. Because it exerts a broad effect upon the tissues of the urethra and the bladder Rye Pollen Flower, offers benefits to women as well as men. Women experiencing an involuntary loss of urine when laughing, coughing, lifting a heavy object, or sneezing, or find them being woken from a deep sleep to urinate, will benefit from taking Rye Pollen Flower to enhance and promote better bladder control.
• Rye Pollen Flower is also a potent antioxidant, immune system enhancer, liver protector, and has energy/anti-fatigue effects. Rye Pollen Flower has been used in clinical settings to promote better wound healing, shorten convalescence time after surgery, and enhance sports performance
• Rye Pollen Flower is a specialized extract designed for the purpose of promoting urogenital health. It is a proprietary combination of water-soluble and lipid-soluble fractions prepared from a defined set of flower pollen sources. The main ingredient is rye pollen. All possible allergens and impurities are removed by a very sophisticated and complex process. The active ingredients are standardized according to proprietary amino acid and phytosterol content profiles, which assures you a consistent product every bottle, every time. There have been no reported serious toxic or allergenic reactions for decades, and no issues of intolerance. Caution is advised for those using flower pollen extracts from unknown origins.

Rye Pollen Flower was developed through a proprietary process that requires the pollen of 10,000 plant tops to produce one kilogram of extract. All possible allergens and impurities are removed, and then a very sophisticated process is used to extract out the hydrophilic and the lipophilic fractions, both of are active in genitor-urinary tract issues. For example, the lipophilic fraction has demonstrated an inhibition of the 5-alpha-reductase (responsible for the production of DHT) as well as the cyclooxygenase pathway, which is involved in the inflammatory process. The hydrophilic fraction has demonstrated anti-proliferative actions against the prostate cells. In other words, it helps to defend the prostate against problematic cell growth.

Mechanisms of Action

• Relaxes smooth muscles, and helps facilitate voiding of the bladder and reduce residual urine
• Improves bladder contractility (and control)
• Inhibits prostate epithelial and stromal cell growth
• Inhibits the arachidonic acid cascade, which is involved in inflammatory processes
• Potent antioxidant properties
• Reduces the effects of cadmium (a suspected inducer of prostate enlargement)
• Protects the liver from some toxins
• Enhances immune system function

The following properties of pollen extracts serve to help protect the prostate from enlargement:

• Inhibits the formation of DHT by inhibiting alpha-reductase enzyme activity
• Improves the clearance of DHT and its end products from prostate cells
• Effectively increases zinc levels in the prostate, and zinc exerts a major impact upon the clearance of DHT. (Taking zinc orally will not necessarily increase levels of zinc in the prostate.)
• Reduces the binding of DHT to its prostate cell receptor site (alpha 1-receptor)

IP6 contains 500 mg of purified Inositol hexaphosphate (IP6) from brown rice extracted in Japan. IP6 is a phosphorylated form of Inositol commonly found in fiber-rich plant foods. IP6 is hydrolyzed by phytase enzymes in the digestive tract to yield inositol. IP6 supports natural cell defense against damaging hydroxyl free radicals by chelating with reactive iron

Curcumin is a potent antioxidant with specific antiviral, anti-inflammatory, anti-cancer and cholesterol-lowering effects.

Curcumin is especially recommended for hepatitis C patients. One study found it to be more effective than green tea extract in suppressing viral damage to liver cells. Curcumin induces cancer cell apoptosis. Apoptosis can be defined simply as programmed cancer cell death. Cancer researchers are focusing in on agents that induce apoptosis as the next generation of cancer drugs. Many of the nutrients in the cancer treatment protocol such as selenium, vitamin A, green tea and vitamin D3 induce apoptosis.

The most effective nutrient available to induce apoptosis may be curcumin. Curcumin is an antioxidant extract from the spice turmeric that produces a wide range of health benefits. Cancer patients should be taking 2000 mg to 4000 mg a day of curcumin extract with a heavy meal. In a wide range of cancer cells, curcumin has been shown to induce cell shrinkage, chromatin condensation, DNA fragmentation and block cellular signal transduction, all of which are characteristics of apoptosis according to an article published in the journal Nutrition and Cancer USA

Peruvian Cat's Claw (Uña de Gato) bark (Uncaria tomentosa).

This amazing vine from the Peruvian rain forest is a powerful anti-inflmmatory with curative properties are almost unlimited. This is because the herb is considered a powerful cellular reconstitutor. Studies beginning in 1970 and continuing through today suggest it has applications in the treatment of bladder and prostate infections, cancer, arthritis, gastritis, ulcers, rheumatism, acne, organic depression, bursitis, genital herpes and herpes zoster, allergies, systematic candidiasis, diabetes, lupus, chronic fatigue syndrome, PMS, irregularities of the female cycle, environmental toxic poisoning, numerous bowel and intestinal disorders and those infected with the HIV virus.

Studies done at the Shanghai College of Traditional Chinese Medicine indicate that rynchophylline, an alkaloid contained in cat's claw bark, has the ability to inhibit platelet aggregation and Thrombosis, which suggests that the compound in this plant may be useful in preventing strokes and reducing the risk of heart attack by lowering blood pressure, increasing circulation, and inhibiting both the formation of plaque on the arterial walls and the formation of blood clots in the brain, heart and arteries. Do not use with anti-ulcer medications. Not recommended if pregnant or nursing.

Green Tea Parts used and where grown: All teas (green, black, and oolong) are derived from the same plant, Camellia sinensis. The difference is in how the plucked leaves are prepared. The leaves of the tea plant are used both as a social and medicinal beverage. Green tea, unlike black and oolong tea, is not fermented, so the active constituents remain unaltered in the herb.

The known health conditions where green tea has been found to be an effective treatment or preventative:

• cancer risk reduction
• gingivitis (periodontal disease)
• high cholesterol
• high blood pressure
• high triglycerides
• immune function
• prostate health

Historical or traditional use: According to Chinese legend, tea was discovered accidentally by an emperor 4,000 years ago. Since then, traditional Chinese medicine has recommended green tea for headaches, body aches and pains, digestion, depression, immune enhancement, detoxification, as an energizer, and to prolong life. Modern research has confirmed many of these health benefits.

Active constituents: Green tea contains volatile oils, vitamins, minerals, and caffeine, but the active constituents are polyphenols, particularly the catechin called epigallocatechin gallate (EGCG). The polyphenols are believed to be responsible for most of green tea's roles in promoting good health.1

Research demonstrates that green tea guards against cardiovascular disease in many ways. Green tea lowers total cholesterol levels and improves the cholesterol profile (the ratio of LDL cholesterol to HDL cholesterol), reduces platelet aggregation, and lowers blood pressure.2 3 4 5 The polyphenols in green tea have also been shown to lessen the risk of cancers of several sites, stimulate the production of several immune system cells, and have anti-bacterial properties -- even against the bacteria that cause dental plaque.6 7 8

Resveratrol is the potent anti-aging compound found in red wine and tha thas been found to cut a man's risk of prostate cancer in half. Not only that but the protective effect appears to be strongest against the most aggressive forms of the disease, according to a new study led by investigators at Fred Hutchinson Cancer Research Center. The findings, by Janet L. Stanford, Ph.D., and colleagues in Fred Hutchinson's Public Health Sciences Division, appear online in The International Journal of Cancer.

"We found that men who consumed four or more glasses of red wine per week reduced their risk of prostate cancer by 50 percent," Stanford said. "Among men who consumed four or more 4-ounce glasses of red wine per week, we saw about a 60 percent lower incidence of the more aggressive types of prostate cancer," said Stanford, senior author of the study. "The more clinically aggressive prostate cancer is where the strongest reduction in risk was observed." That compound in red wine, Stanford and colleagues found, is an antioxidant called resveratrol, which is abundant in the skins of red grapes but much less so in the skins of white grapes. The compound is also found in peanuts and raspberries and is available as a dietary supplement, which has been suggested to protect against cardiovascular disease. Laboratory studies indicate that resveratrol influences a variety of biological pathways that are important in cancer development. For example:

• As an antioxidant, it helps sweep dangerous, cancer-causing free radicals from the body.
• As a potent anti-inflammatory agent, it blocks certain enzymes that promote tumor development.
• The compound also reduces cell proliferation, curtailing the number of cell divisions that could lead to cancer or the continued growth of cancer cells.
• It also enhances apoptosis, or programmed cell death, which helps rid the body of cancerous cells.
• It may act as an estrogen, reducing levels of circulating male hormones such as DHT that fuel the growth of prostate cancer.

The metabolic process that generates energy at the cellular level in our body is called thermogenesis. While thermogenesis has typically been categorized as a key factor in weight loss, to confine the scope of its function to this aspect alone is incomplete. Thermogenesis plays an integral role in our body's ability to properly utilize the daily foods and nutrients we take in. It sets in motion the mechanisms that lead to digestion and subsequent gastrointestinal absorption. Piperine, in the patented form of BioperineT enhances the body's natural thermogenic activity - hence the term ThermonutrientT.

This combination of natural supplements can be very helpful to improve prostate health.

Zinc Picolinate is natural delivery from of Zinc –an essential mineral in human and animal nutrition with a wide range of biological roles. Zinc is required for a number of immune functions. Picolinic acid is produced in the pancreas and forms a complex with Zinc. This biochemical complex facilitates the passage of zinc through the gastrointestinal wall and into the circulatory system.

Thus Zinc Picolinate represents a natural and optimal delivery form of zinc, with the added advantage of greater tolerance, better absorption dynamics and greater safety.

Requirements

The Food and Nutrition Board of the Nutrition Board of the National Academy of Sciences has recommended the following Recommended Dietary Allowances (RDA) for zinc.

Picolinic acid as a delivery form of Zinc

In order for minerals in food to be utilized within the cells of the body, they must first be extracted from food, carried through the intestinal membranes, transported in the blood stream, and finally carried through the cell membrane to the interior cellular mechanisms. There are several barriers to this process. The most difficult being the intestinal wall. The cells that line the intestinal wall present a negative charge on the membrane surface. Minerals that have been dissolved in the digestive fluid which have lost their neutrality and have become positively charged will be attracted to the membrane and held tightly. In this instance, the minerals will not be allowed to pass through, and will remain held to the wall until another secretion cleanses them away. A process called chelation accomplishes this feat for some of the minerals, while for others the electrical charge attraction is as strong. Chelators are organic molecules that have their electrical charges arranged in such a way as to attract the positively charged mineral and temporarily tuck the mineral into a larger complex. Thus, with the mineral ion’s positive charge shielded by the large chelator molecule, the complex appears to be neutral or negatively charged and will not be held by the membrane as it passes through.

Picolinic acid is the body’s prime natural chelator. There is an important reason for the body to construct this molecule. It is the most efficient chelator for minerals such as chromium, zinc, manganese, copper, iron, and perhaps molybdenum.

Picolinic acid is produced from the amino acid tryptophan in the liver and kidneys, and is transported to the pancreas. During digestion, Picolinic acid is secreted from the pancreas into the intestine.

Mineral uptake by tissues is far greater when then mineral is a Picolinate, rather than the other forms. Since our bodies utilize picolinic acid to absorb and transport certain minerals, and our cells recognize mineral picolinates and readily use them, it makes sense to design mineral supplements based on this knowledge.

Role of Zinc in human nutrition

Zinc is involved in number of biologically important processes in human system

• Normal growth and development: Zinc plays important roles in bone growth and mineralization and the development of reproductive organs.
• Maintaining healthy skin and bones: Zinc deficiency is linked to various skin disorders, including eczema, acne, and excessive flaking similar to what occurs in psoriasis. Hair becomes dull and lifeless looking.
• Metabolic processes: Zinc is a component of various enzyme systems, and it is essential for the synthesis and metabolism of proteins and genetic material. The red blood cells also need zinc for the proper transfer of carbon dioxide.
• Healing and immune function: Zinc promotes the healing of burns common infections.
• Taste and smell: Zinc’s role in these senses enables a person to distinguish the taste of different foods.

Physiologically, zinc is vital for growth and developments, sexual maturation and reproduction, dark vision adaptation, olfactory and gustatory activity, insulin storage and release and for a variety of host immune defenses, among other things. Zinc deficiency can result in growth retardation, immune dysfunction, increased incidence of infections, hyypogonadism, oligospermia, anorexia, diarrhea, weight loss, delayed wound healing, neural tube defects of the fetus, increased risk for abortion, alopecia, mental lethargy and skin changes.

Zinc may have immunomodulatory activity. Zinc has putative antiviral, fertility- enhancing and retinoprotective activities.

Zinc is also very important to the newborn when breast milk may be its only source of Zinc.

Zinc is needed for the development of neutrophils and natural killer cells in the non-specific immune defense as well as acquired immunity that is attained through the activities of T-lymphocytes and B-lymphocytes.

The usefulness of Zinc to promote wound healing in the presence of low plasma zinc has been firmly established.

Use of zinc promoted the repair process of the damaged vascular tissue through stimulus of the lipoxygenase pathway that mediates response to endogenous growth factors in the healing process. Zinc compounds also hasten the healing of gastric ulcers.

It is observed that the common theme throughout research points to the fact that zinc plays an essential role in tissue healing.

Deficiency symptoms

Even borderline zinc deficiency or disturbances in Zinc metabolism can have profound adverse health effects. Those at greatest risk of such deficiencies and disturbances include infants, children, and the elderly and pregnant women. Due to conditions that can limit the bioavailability of zinc, even when there is adequate zinc intake, zinc deficiency may affect still larger population.

Among diseases and conditions associated with zinc deficiency are alcoholism, malabsorption syndromes, acrodermatitis enteropatica, anorexia nervosa, thermal burns and total parental nutrition without zinc supplementation.

Zinc Picolinate as a nutritional supplement

The study was a double-blind, placebo-controlled, cross-over clinical trial, and the results showed that red blood cell levels, blood serum levels, and hair levels of zinc all improved best with zinc Picolinate.

Supplement users, in fact, note that since zinc Picolinate is so well assimilated, the amount needed may be only one-third as much as normally taken for supplemental Purposes.

Zinc Picolinate is absorbed in the body to a higher degree than various other inorganic salts.

Zinc Picolinate has the greatest efficacy in reversing the zinc deficiency in acrodermatitis enteropathica, a rare genetic disorder.

Picolinic acid is a tryptophan metabolite. Patients with acrodermatitis enteropathica have a defect in the metabolism of tryptophan, which leads to picolinic acid deficiency. Zinc Picolinate helps to correct this deficiency.

Administration of zinc as zinc Picolinate is effective for patients with zinc deficiency and idiopathic taste disorder.

Reference

1. Singer, Mc Elvain, Org. Syn. Co11 –Vol. III, 740 (1995)
2. Oliveto, Part3, E. Klingsberg, EL. (Interscience, New York, 1962) p 179.
3. Cuajungco MP, Lees GJ. Neurobiol Dis. 4:137-169 (1997)
4. Fabris N, Mocchegiani E. Aging Clin Exp Res. 7:77-93 (1995)
5. King JC, Keen CL.Zinc.In: Shils, ME, Olson JA, Shike M, Ross AC, eds: Williams and Wilkins; 223-239 (1999)
6. Mc Mahon RJ, Cousins, RJ. J. Nutr. 128:667-670 (1998)
7. Sturniolo GC, Di Leo V., Barollo M, et al. J Trace Elem. Exp. Med, 13:33-39 (2000)
8. Prasad A.S. J Am. Coll. Nutr. 15:113-120. (1996)
9. Prasad A.S. Am J Clin. Nutr. 53:403-412 (1991)

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Selenium Select : a bioavailable and safe form of selenium supplementation
Selenium Select L(+)- SELENOMETHIONINE

CAS # : 3211-76-5

Synonym : (S)-(+)-2-Amino-4(methylseleno)-butanoic acid

Specific rotation: between +17.0o and +19.5o (Test solution: 10mg per ml, in 1 N HCL)

Sabinsa Corporation offers manufacturers two grades of L-(+) Selenomethionine:

• Pure L-(+)-Selenomethionine (containing a minimum of 40% elemental selenium)
• A triturated product with dicalcium phosphate, which contains 5,000 mcg per gram (0.5% elemental selenium).

It is important to recognize that "chelates" and "organically bound" forms of selenium are not similar to Sabinsa’s L-(+)-Selenomethionine. Both these forms release inorganic selenium into the body. Sabinsa’s product is unique in that the selenomethionine is a single chemical entity containing molecularly integrated selenium.

• This makes L-(+)-Selenomethionine not only safer, but more bioavailable than other dry "blended" selenium and methionine products. Organically bound selenium has garnered heavy media attention as a pivotal component in the body’s detoxifying system and for its role in the prevention of disease.
• L-(+)-Selenomethionine administered in the form of selenomethionine containing yeast was found to be effective in reducing the risk of cancer in a significant study. L-(+)-Selenomethionine is the preferred form of selenium supplementation due to its inherent safety and its scientific recognition as the most bioavailable form of selenium.